DriverMap Adaptive Immune Repertoire (AIR) Profiling Service

The DriverMap Adaptive Immune Repertoire (AIR) Profiling Service from Cellecta provides you with a profile of all TCR and BCR CDR3 regions in blood, cell, or RNA samples.

With the DriverMap AIR Profiling Service, you get

  • a larger complement of clonotypes than other similar assays
  • reproducible and comprehensive coverage from a range of immune sample inputs, including total RNA from whole blood
  • Rapid, 1-month turnaround

General information

Cellecta’s DriverMap™ AIR assay is designed to specifically amplify only functional CDR3 RNA molecules' TCR and BCR cells, avoiding non-functional pseudogenes with similar structures. The assay simultaneously amplifies, in a single, multiplex RT-PCR reaction, all TCR and BCR CDR3 regions using a set of 300 experimentally validated PCR primers to yield Illumina-compatible next-generation sequencing (NGS) libraries.

Additionally, samples submitted for profiling using the DriverMap AIR Profiling Service can be run, in parallel, through our standard DriverMap Targeted Gene Expression Profiling assay to generate gene expression profiles that provide phenotypic information for cell typing.

Do you have immune samples you would like to profile? Provide us with some information on your samples and your study goals, and we will get back to you about early access to our DriverMap Adaptive Immune Repertoire Profiling program.

Download the product flyer for a general overview.

We have also developed RNA Spike-In Controls for use within RNA-based AIR-seq assays. Download details here.

Watch the webinar Immunophenotyping of TCR and BCR Clonotypes (26 min) for more information. 

Poster: Immunophenotyping of TCR and BCR Clonotypes

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