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March 29 – April 3, 2019, Georgia World Congress Center, Atlanta, GA
Come see us at Booth 4218.
I. Poster Abstract 3426: Tuesday, April 2, 2019 – 8:00 a.m. to 12:00 p.m.
Combining cell barcoding and CRISPR sgRNA libraries with targeted gene expression for single-cell genetic analysis of tumor metastasis
II. Educational Workshop: Spotlight Theatre C, Tuesday, April 2, 2019, 3:00-4:00 p.m.
Genetic Profiling and Functional Screening for Drug Target and Biomarker Discovery
Presenters:
Speaker 1: Paul Diehl, PhD, COO, Cellecta
Talk: Efficient tools to enable drug target and biomarker discovery: a brief introduction to Cellecta technologies
Speaker 2: Ian P. Winters, PhD, Director of Research, D2G Oncology
Talk: Quantitative and multiplexed in vivo functional cancer genomics using barcoded CRISPR libraries
Large-scale sequencing of human tumors has uncovered a vast array of genomic alterations. Genetically engineered mouse models recapitulate many features of human cancer and have been instrumental in assigning biological meaning to specific cancer-associated alterations. However, their time, cost- and labor-intensive nature limits their broad utility; thus, the functional importance of the majority of genomic aberrations in cancer remains unknown. Here, we combine genetically engineered mouse models of cancer with CRISPR-mediated genome editing, DNA barcoding, and next-generation sequencing to simultaneously investigate the function of many genomic alterations in vivo and uncover novel biological and clinically actionable insights into carcinogenesis.
Register here. Space is limited.
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