CRISPR vs. RNAi Dropout Viability Screens Similar loss-of-function dropout screens using CRISPR technology to knock out, rather than knock down, genetic targets have been shown to be an attractive alternative to RNAi-based screens. How do these two complementary screening approaches compare?
TGF-β Enrichment Screen A genetic screen experiment performed in collaboration withDr. Peiqing Sunat The Scripps Research Institute was designed to identify modulators that confer resistance to TGF-β-induced apoptosis in the Hep3B human hepatocellular carcinoma cell line.
Prostate Cancer Viability Screen The goal of this screen was to identify genes and corresponding androgen-dependent and independent signaling pathways which are critical for viability of prostate cancer cells but are not essential for cells of other tissue types. This study was made possible by NIH NCI Grant # 1R43CA134062-01, entitled “Viability Pathway Models in Prostate Cancer Cells.”