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CRISPR sgRNA Constructs, Vectors, and Cells

The CRISPR/Cas9 system can be used to knock out gene expression in vivo or in vitro by using a combination of an sgRNA (single guide RNA, or gRNA) along with a Cas9 nuclease. With clonal selection you can obtain permanent 100% knockout in your cells.

  • Cellecta will design and clone sgRNA to any gene target of interest
  • You get plasmid or VSV-G pseudoviral packaged sgRNA constructs to knock out your gene target in your cell model
  • We can also make you knockout or knock-in cell lines with our "Zero Footprint" transient sgRNA and Cas9 approach

  • Achieve complete knockout of your gene with our reliable and precise CRISPR lentiviral constructs, available as plasmids or packaged, transduction-ready, lentiviral particles. Pick your gene of interest, choose your options, and we do the rest.

    As an alternative, choose your gene of interest and cell background, and Cellecta will build a custom knockout, knock-in, or other engineered cell line for you.

  • Cellecta can provide either constitutive or tet-inducible sgRNA constructs targeting your gene of interest with a range of selection markers. Vector options are available for both all-in-one constructs containing the Cas9 gene or sgRNA-only formats.

    We can also provide verified knockout or knock-in cell lines using our "Zero Footprint" procedure.

  • The CRISPR/Cas9 system enables gene knockout, knockdown, activation, or knock-in using sgRNA and Cas9 nuclease.

    Engineered Cas9 variants enable gene regulation without altering DNA structure.

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