Webinar: Network-anchored functional genomics identifies intra-tumoral axes of vulnerability in pancreatic cancer

Date: Wednesday, October 28, 2020

Time: 8:00 am - 9:00 am USA Pacific Time (PDT); 10:00 am - 11:00 am USA Central Time (CDT); 4:00 pm - 5:00 pm Central European Time (CET)

Speakers: Johnathon Rose, MD Anderson Cancer Center; Sanjana Srinivasan, MD Anderson Cancer Center; Dr. Paul Diehl, COO, Cellecta

          

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, in part attributed to recurrence following standard-of-care treatment. In this webinar, the speakers will discuss the development of an integrated platform to inform on intra-tumoral vulnerability context from gene-cluster trends.

Leveraging a representative patient-derived xenograft cohort, the platform was used to integrate a PDAC co-expression network (PCEN) with customized  in vivofunctional genomics to define cluster-anchored vulnerabilities. This enabled characterization of PCEN representation intra-tumorally, and feature-barcoded, single-cell analysis was then used to validate subcellular targeting following PCEN-informed CRISPR perturbation.

In this webinar, you will learn:

  • How transcriptome data was used to get insight into PDAC
  • How functional genomics was integrated with disease-specific networks to establish dependency context 
  • How to validate intra-tumoral targets and deal with tumor heterogeneity

A brief overview of Cellecta technologies and live Q&A session will follow the presentation.

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