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Synthetic LethalityshRNA library screening

Custom Library from Cellecta Helps Identify BRM/SMARCA2 as a Critical Target in Cancers

March 12, 2014

Dr. Gregory Hoffman's group from Novartis recently used a custom library from Cellecta that identified BRM/SMARCA2 as a critical target in BRG1-deficient cancers (PMID: 24520176). The shRNA library consisted of 6500 shRNAs (380 genes with 17 shRNAs per gene) involved in epigenetic regulation. These genes represented...