Basel Life 2019

September 9-12, 2019, Congress Center Basel, Switzerland

Stop by and see us at Stand D05.

Symposium: Thursday, September 12, 2019, 13:15 – 14:15 h – Samarkand Room

Genetic Profiling and Functional Screening for Drug Target and Biomarker Discovery

Pooled libraries of heterogenous lentiviral constructs have proven to be a highly effective approach to individually label cells in a target population with cell-specific barcodes and/or other genetic effectors, such as CRISPR sgRNA targeting different genes. The transduced populations can then be analyzed by NGS to identify sub-sets of cells with specific traits or phenotypic responses which indicate the essentiality of particular genes or activation of certain pathways. In contrast, NGS analysis of targeted multiplex RT-PCR from cell and tissue samples, even down to single cell levels, enables parallel analysis of differences in gene activation across and within cell populations as a result of perturbation or selection. This presentation will discuss how these approaches can be used to gain a more comprehensive understanding of relevant and critical genetic pathways in cell models and diseased tissues.

Presenter: Paul Diehl, PhD, COO, Cellecta

View Event

Also in Events, Conferences, Meetings

2019 American Society of Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) Annual Meeting

December 7-11, 2019, Walter E. Washington Convention Center, Washington, DC
Read More
9th Drug Discovery Innovation Programme

October 22-23, 2019, Westin San Francisco Airport, Millbrae, CA More>
Read More
American Society of Human Genetics (ASHG) Annual Meeting

October 15-19, 2019, George R. Brown Convention Center, Houston, TXStop b...
Read More