Webinar: Phenotypic screening hit target deconvolution using pooled CRISPR/Cas9 screening technology

Date: Tuesday, May 18, 2021

Time: 9:00 am - 10:00 am USA Eastern Time (ET); 06:00 am - 07:00 am USA Pacific Time (PT)

SpeakersBarbara Nicke, Ph.D., Director of Therapeutic Compound Research, Nuvisan ICB GmbH, Germany; Dr. Paul Diehl, COO, Cellecta 

             
Cellecta and Nuvisan Innovation Campus, Berlin bring you an excellent case-study presentation on Phenotypic Screening Hit Target Deconvolution using Pooled CRISPR/Cas9 Screening Technology held at the 2021 Americal Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference.

Abstract:

This study will outline a target deconvolution strategy for novel potent small molecule inhibitors of YAP1/TAZ activity identified in a high-throughput screen of 3.8 million compounds. As a way to find the molecular target of the identified lead compound, pooled CRISPR/Cas9-KO screening targeting about 6000 human genes was conducted. PGGT1B, a subunit of the geranylgeranyltransferase I (GGTase I) complex, was validated as the direct target of the YAP1/TAZ pathway inhibitor.

In this presentation, you will learn about the:

  • Design of a CRISPR/Cas9-based target deconvolution study
  • Validation of the screening strategy
  • Verification of the identified target

A brief overview of Cellecta technologies and their application for drug target discovery and validation will follow the presentation.

Register Now
Please email info@cellecta.com with any comments.


Also in Events, Conferences, Meetings

Association for Molecular Pathology Annual Meeting & Expo 2024

November 19 - 23, 2024
Read More
Society for Immunotherapy of Cancer Annual Meeting 2024

November 6 - 10, 2024
Read More
Immuno US 2024

October 28 - 29, 2024
Read More