DKFZ

Researchers Identify SALL1 as a Tumor Suppressor in Breast Cancer with a Role in E-Cadherin Regulation

January 17, 2014

Researchers at the German Cancer Research Center (DKFZ) and the MD Anderson Cancer Center used Cellecta's shRNA DECIPHER Libraries for an in vivo genetic screen that identified SALL1 as a breast cancer tumor suppressor that plays a role in E-cadherin regulation (Article)E-cadherin (CDH1) has been shown to have a...

German Researchers Find Sensitizer for Gemcitabine Using DECIPHER RNAi Libraries

June 10, 2013

Article Cancer DECIPHER disease DKFZ drug targets lethal Pooled shRNA Library RNAi Screen RNAi Screening shRNA shRNA Library Synergistic Lethality synthetic lethality Synthetic Lethalityarticle

Researchers at the German Cancer Research Center (DKFZ) used Cellecta's shRNA DECIPHER libraries to identify genes that sensitize pancreatic cells to gemcitabine.Pancreatic cancer has only a 6% 5-year survival rate. Gemcitabine is the standard treatment in conjunction with surgery to remove cancerous...