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Single-Cell Genetic Analysis 

Single-cell genetic analysis provides a powerful way to understand how genetic variability among individual cells drives biological differences. Unlike bulk sequencing methods that average signals across a population, single-cell approaches reveal distinct cellular phenotypes, uncover subpopulation dynamics, and identify rare but biologically important events.

  • Get In-Depth Insights

    • Tumor Heterogeneity and Clonal Evolution
    • Immune Repertoire Mapping and Antigen Response Characterization
    • Drug Resistance Mechanisms and Biomarker Discovery
    • Differentiation, Stem Cell Development, and Hematopoiesis
    • Vaccine and Antibody Discovery
    • Neoantigen Identification and Immunophenotyping
    • Modeling Lineage Plasticity in Cancer and Development

  • Cellecta’s Single Cell Technology Portfolio

    Cellecta provides several technologies and services that enable researchers to explore genetic and transcriptional heterogeneity, monitor clonal lineage, assess immune receptor diversity, and identify gene-function relationships—one cell at a time.

    Pooled CRISPR Screens with Single-Cell RNA Sequencing (scRNA-seq, CRISP-seq, Perturb-Seq, CROP-Seq, etc.)

    • Investigate the effect of gene knockouts, inhibition, or activation on gene expression.
    • Study transcriptional changes associated with >100 gene targets in a single experiment.
    • Identify regulatory relationships missed in bulk arrayed screens.

    Lineage Tracing of Cells and Clones with Barcode Libraries and Individual Constructs

    • Track clonal evolution and cellular responses with stable, heritable barcodes.
    • Study tumor progression, drug resistance, differentiation, and development.
    • Identify genotypic differences between sub-clonal populations that exhibit differential responses or phenotypes.
    • Assess cell heterogeneity in response to environmental challenges or therapies.

    Identification of TCR/BCR Chain Pairs in Single Cells (scAIR)

    • Profile adaptive immune receptor chains at single-cell resolution.
    • Obtain full-length α/β (TCR) or IGH/IGK/IGL (BCR) chain-pair sequences.
    • Analyze T-cell or B-cell subtype markers in parallel with receptor chain-pair matches.

  • Cellecta’s Single-Cell Technology Provides the Following

    • Cost-effective Workflows: microtiter assay formats and scalable services for generating single-cell data at reasonable cost.
    • Custom Services and Assay Development: tailored services for perturbation-based analysis, lineage tracking, and receptor profiling in both human and mouse models.
    • Accessible Platform: no need for microfluidics or droplet-based instruments—Cellecta’s plate-based systems work with standard lab equipment.
    • Bioinformatics Analysis: downstream analysis services and interpretation support from Cellecta’s bioinformatics team.

  • More Information

    1. CloneTracker™ Barcode Libraries
    2. Custom Barcode Libraries
    3. Single Barcode Constructs
    4. Single-Cell CRISPR Screening Service
    5. DriverMap™ Single-Cell AIR Kits
    6. DriverMap™ Single-Cell AIR Profiling Service

  • FAQs