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Multiplex PCR for Gene Expression & Immune Receptor Profiling 

Powered by Cellecta’s proprietary primer design pipeline and optimized multiplex PCR workflow, our DriverMap™ Multiplex Targeted PCR Assays provide highly sensitive, targeted analysis of gene expression and immune receptor repertoires through proprietary multiplex PCR assays coupled with next-generation sequencing (NGS). Multiplex PCR amplification of specific targeted amplicons provides precise and reproducible quantification that enables researchers to efficiently quantify expression levels of tens of thousands of protein-coding genes and survey the diversity of hundreds of thousands of T- and B-cell receptor (TCR /BCR) clonotypes—even in limited and rare samples.

Gene Expression Profiling with Unmatched Sensitivity and Reproducibility

The DriverMap Expression Profiling (EXP) Assays enable rapid and sensitive whole-transcriptome gene expression profiling from total RNA for biomarker discovery and differential expression studies. The assay is compatible with complex samples such as FFPE, dried blood, or xenografts. Since there is no requirement for rRNA depletion or mRNA enrichment, the DriverMap EXP assay is ideal when profiling small samples and limited amounts of cells. In fact, with low numbers of cells, including fine-needle aspirate (FNA) samples, expression can be assayed directly in cell lysate.

Some applications:

  • Biomarker discovery and stratification for precision medicine
  • Gene expression profiling in preclinical models, patient-derived samples, and clinical trial cohorts
  • Transcriptomic analysis in single-cell or low-input RNA settings, including dried blood microsamples
  • Detection of clonal expansion, activation signatures, and treatment-associated shifts in TCR/BCR composition

Immune Receptor Profiling (Bulk, Single-Cell, Cell-Free Samples)

The comprehensive range of DriverMap Adaptive Immune Receptor (AIR) Assays offers both RNA- and DNA-based profiling of T-cell and B-cell receptors (TCRs/BCRs) in bulk cell populations or individual cell-by-cell analysis. Assays provide sensitive detection of the CDR3 regions, full-length regions for RNA, or paired-chain sequences for all TCR or BCR variants. Proprietary targeted primers enable rapid and accurate identification of clonotypes from isolated blood, PBMCs, bulk, fractionated, plasma-derived, or sorted T-cells and B-cells, or full receptor--TCR alpha/beta or BCR heavy/light chain pairing information.

  • Immune repertoire characterization in cancer immunotherapy, autoimmune diseases, and infectious disease research
  • Detection of shifts in TCR/BCR composition or abundance in response to treatment, vaccinations or antigen exposure
  • TCR/BCR chain pairing studies for neoantigen-targeting therapies and CAR-T development
  • Validation of immune checkpoint inhibitors and antibody therapeutics

Get Started

Whether you're working with whole blood, frozen tissue, PBMCs, or single cells, simply contact Cellecta to discuss your experimental goals. We offer off-the-shelf kits for genome-wide expression and immune receptor profiling, as well as contract profiling services for analysis of researcher-submitted samples. Further information is available below:

  1. DriverMap EXP Gene Expression Kits
  2. DriverMap EXP Gene Expression Services
  3. DriverMap AIR Profiling Assays
  4. DriverMap AIR Profiling Services
  5. DriverMap Cell-Free Profiling Assays
  6. DriverMap EXP and AIR Analysis Services

For a sampling of peer-reviewed publications and citations of Cellecta products and services, please visit and search for your product or application of interest on this page.

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