AACR Annual Meeting 2026

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Applications for TCR Repertoire Profiling: Bridging the Gap between Repertoire Frequency and Functional Specificity

Speaker 1: Dr. Katharina Lindner, Postdoctoral Researcher, Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology at the German Cancer Research Center 

 

Identification and Tracking of Antigen-Specific T Cell Receptors in Cancer Patients by High-Throughput TCR Sequencing

Granular profiling of antigen-specific T cell receptor (TCR) repertoires remains a challenge in cancer immunology. We describeESPEC-SUIT, a sequencing-based platform integrating peptide-drivenin vitro expansion of antigen-specific CD4⁺ and CD8⁺ T cells with TCR repertoire analysis. Antigen-stimulated cultures undergo bulk TCRβ sequencing to define expanded clonotypes, enabling downstream tracking, cloning and functional validation of TCRs. Applied longitudinally, ESPEC-SUIT captures dynamic changes in antigen-specific TCR repertoires and supports tracking of clonotypes across blood and tumor samples, which we demonstrate in a cohort of neoepitope-vaccinated glioma patients. ESPEC-SUIT enables scalable, comprehensive and sensitive interrogation of tumor-reactive TCR landscapes for immuno-oncology research.

Speaker 2: Alex Chenchik, Ph.D., Cellecta President & Chief Scientific Officer

From Repertoire to Response: A Workflow for Mapping Antigen-Driven T and B Cell Clonotypes

We will present an integrated immune profiling workflow that links repertoire sequencing with functional validation to rapidly identify antigen-specific T and B cell clonotypes. By combining bulk and single-cell AIR profiling with multiplexed receptor pairing and reporter-based screening, it enables high-confidence epitope discovery for immuno-oncology applications, biomarker development, and targeted immunotherapy design.

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II. Posters

POSTER NUMBER 4249: High-throughput discovery of MART1-specific TCR-peptide interactions using a Jurkat NFAT Reporter-K562 antigen-presenting cell system and single-cell adaptive immune receptor profiling

Presented by: Alex Chenchik, Ph.D., Cellecta President & Chief Science Officer

Tuesday, April 21 from 9:00 am - 12:00 pm in Poster Section 6, Poster Board Number 17

Abstract Number: 6807

POSTER NUMBER 6515: High-throughput, 96-well plate-based single-cell TCR sequencing for scalable chain-pairing and immunophenotyping of cancer-associated T-cells

Presented by: Alex Chenchik, Ph.D., Cellecta President & Chief Science Officer

Tuesday, April 21 from 2:00 - 5:00 pm in Poster Section 43, Poster Board Number 4

Abstract Number: 5552