American Association for Cancer Research Annual Meeting 2022






April 8-13, 2022, Ernest N. Morial Convention Center, New Orleans, Louisiana

Come see us at Booth 2618.

I. Poster Abstract 625: Sunday, April 10, 2022, 1:30 – 5:00 p.m. – Poster Board No. 10

Immunophenotyping of TCR and BCR clonotypes

II. Poster Abstract 3426: Tuesday, April 12, 2022 – 1:30 – 5:00 p.m. – Poster Board No. 18

Perturb-seq analysis of TNFα-induced transcriptional response

III. Educational Symposium: Spotlight Theatre A, Tuesday, April 12, 2022, 3:00-4:00 p.m.

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CRISPR & RNAi Genetic Screening and other Methods for the Discovery of Oncogenic Vulnerabilities and Drug Resistance

Moderator: Paul Diehl, PhD, COO, Cellecta 

Speaker 1: Maria J. Ruiz-Echevarria, PhD, Associate Professor, Stephenson Cancer Center, Oklahoma Health Sciences Center
Talk: Development of a multitargeted therapy for prostate cancer

Relapse after first-line androgen deprivation therapy (ADT) is the main cause of mortality in patients with advanced prostate cancer (PCa). Key molecular mechanisms of resistance reveal continued activation of the androgen receptor (AR). To enable the development of multitargeted therapeutics for PCa, we have developed an unbiased RNA interference (RNAi) based negative selection screen to identify shRNAs that cause toxicity in cellular models of relapsed disease after ADT, by targeting multiple AR-signaling components. The results emphasize the value of this screen for the identification of effective multitarget therapeutic modalities that maximize AR signaling inhibition with theoretically limited resistance profiles.

Speaker 2: Alex Chenchik, PhD, President and Chief Scientific Officer, Cellecta
Talk: Immunophenotyping of TCR and BCR clonotypes

T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding the disease mechanisms and development of new therapeutics for infectious disease, auto-immunity and immuno-oncology applications. However, this potential could be greatly improved by combining information about receptor clonotypes with immunophenotypes of T and B cells. To facilitate these studies, we developed a novel technology for combined profiling of all human TCR and BCR variable regions and phenotypic characterization of immune cells.

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